By Steven A. Olson MD, Farshid Guilak PhD
Bringing jointly the main updated learn on post-traumatic arthritis (PTA) and its administration, this booklet is a entire presentation of the present pondering on all facets of the mechanisms of joint damage and next improvement of PTA. Divided into thematic sections, it contains discussions of the prevalence and burden of PTA, either in society at huge and within the army inhabitants in particular; the appropriate experimental paintings on PTA, from easy technological know-how to animal types; peri-articular tissue responses to of joint damage and capability mechanisms of PTA; the present medical overview and therapy of universal joint accidents resulting in PTA; and rising applied sciences and coverings for PTA, together with biomarkers and stem cellphone remedies. Taken jointly, will probably be a useful source for orthopedic surgeons, rheumatologists and different joint harm researchers and clinicians.
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Extra info for Post-Traumatic Arthritis: Pathogenesis, Diagnosis and Management
Armed Forces, 2003–2011. MSMR. 2012;19(2):18–21. 16. Masini BD, Waterman SM, Wenke JC, Owens BD, Hsu JR, Ficke JR. Resource utilization and disability outcomes assessment of combat casualties from operation Iraqi Freedom and Operating Enduring Freedom. J Orthop Trauma. 2009;23:261–6. 17. Owens BD, Kragh JF, Macaitis J, Svoboda SJ, Wenke JC. Characterization of extremity wounds in Operation Iraqi Freedom and Operation Enduring Freedom. J Orthop Trauma. 2007;21:254–7. 18. Owens BD, Kragh JF, Wenke JC, Macaitis J, Wade CE, Holcomb JB.
12. McKinley TO, Borrelli Jr J, D’Lima DD, Furman BD, Giannoudis PV. Basic science of intra-articular fractures and posttraumatic osteoarthritis. J Orthop Trauma. 2010;24(9):567–70. 13. Buckwalter JA, Brown TD. Joint injury, repair, and remodeling: roles in post-traumatic osteoarthritis. Clin Orthop Relat Res. 2004;423:7–16. 14. Ding L, Heying E, Nicholson N, Stroud NJ, Homandberg GA, Buckwalter JA, et al. Mechanical impact induces cartilage degradation via mitogen activated protein kinases. Osteoarthritis Cartilage.
4 per 1,000 person-years with higher rates in younger, cadet age groups . Because osteochondral lesions of the talus are 3 Arthritis After Joint Injury: The Military Experience associated with ankle instability, the high rate of ankle sprains in this population is important [60, 61]. Osteochondral lesions of the ankle occur at an incidence rate of 27 per 100,000 personyears for men and 31 per 100,000 person-years for military women . As with other studies of joint injury, enlisted rank, service in the Army and Marines, and older age were risk factors associated with osteochondral lesion of the talus.
Post-Traumatic Arthritis: Pathogenesis, Diagnosis and Management by Steven A. Olson MD, Farshid Guilak PhD